This study presents the faunal remains from the Late Pleistocene and Holocene periods, recovered during the 2019 excavation of Wezmeh Cave near Kermanshah. The findings contribute to a deeper understanding of past biodiversity in the Zagros Mountains. This karstic cavity appears to have served as a favorable place for various animals, particularly carnivores. The osteological remains of a wide range of taxa have been identified. Among the carnivores are hyenas, bears, large felids, wolves, and foxes, while herbivore remains include deer, wild boars, equids, rhinoceroses, as well as both wild and domestic sheep, goats, and cattle. The faunal spectrum at Wezmeh Cave is not limited to large and medium-sized mammals; numerous small mammals such as hares, weasels, and porcupines, along with various microvertebrates, are also present. These species either inhabited the cave or were brought there by natural or anthropogenic agents. Preliminary archaeozoological and taphonomic analyses indicate a complex ecological dynamic among species across different temporal phases. The archaeological significance of Wezmeh Cave is underscored by evidence of continuous or repeated occupation since at least 70,000 years ago, offering valuable insights into environmental and faunal changes from the Late Pleistocene through the Early Holocene and beyond. The diversity and richness of this fossil assemblage are unparalleled on the Iranian Plateau and rank among the most significant in Western Asia. This study also complements earlier research that identified the remains of both a Neanderthal child and an Early Neolithic herder-farmer within the cave.